Half-Life of Meds. What does it all mean please?

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Half-Life of Meds. What does it all mean please?

Post by Paddy on Mon Apr 11, 2011 10:19 am

Half-Life of Medications. What Does it all Mean Please someone?

Below is an example from a MedsafeNZ health professionals Data Sheet on the Half-Life details of a medication prescribed to one of our Members.

Is there an easy way of understanding what this Excerpt from the Data Sheet means, for us?

Is it something we need to know, especially when starting, changing or stopping one of our meds?

I appreciate the professionals Data Sheets are more detailed than Consumer Info Sheets, but what does it all mean? E.G.

“Elimination
The elimination half-life of unchanged carbamazepine averages approx. 36 hours following a single oral dose, whereas after repeated administration it averages only 16 to 24 hours (autoinduction of the hepatic mono-oxygenase system), depending on the duration of the medication. In patients receiving concomitant treatment with other liver-enzyme inducing drugs (e.g. phenytoin, phenobarbitone), half-life values averaging 9 to 10 hours have been found.

The mean elimination half-life of the 10,11-epoxide metabolite in the plasma is about 6 hours following single oral doses of the epoxide itself.

After administration of a single oral dose of 400 mg carbamazepine, 72% is excreted in the urine and 28% in the faeces. In the urine, about 2% of the dose is recovered as unchanged drug and about 1% as the pharmacologically active 10,11-epoxide metabolite.”


Thanks, 'cos I'm confused. Embarassed
Paddy.

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Re: Half-Life of Meds. What does it all mean please?

Post by DocLazy on Mon Apr 11, 2011 10:45 am

I don't think it's of much value to us unfortunately. The withdrawal period isn't really effected by the half-life. Venlafaxine, for example, has a really short half-life but can take weeks to come off

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